Orforglipron at a glance
| Detail | What the sources say |
|---|---|
| Type | Small-molecule GLP-1 receptor agonist taken by mouth |
| Developer | Eli Lilly; discovered by Chugai Pharmaceutical |
| US status | Approved on 1 April 2026 as Foundayo™ (weight management) |
| UK status | Authorised by the MHRA in 2026 |
| Phase 3 evidence | Randomised trial in adults with obesity, NEJM 2025 |
What the label describes
| Step | What the label describes |
|---|---|
| Start | 0.8 mg once daily [1] |
| After at least 30 days on 0.8 mg | 2.5 mg once daily [1] |
| After at least 30 days on 2.5 mg | 5.5 mg once daily [1] |
| Next levels | 9 mg, 14.5 mg or 17.2 mg once daily; the label says the dosage may be increased to the next level after at least 30 days on the current dosage, based on treatment response and tolerability [1] |
| Maximum | 17.2 mg once daily [1] |
| With a strong CYP3A4 inhibitor | Maximum of 9 mg once daily (section 2.2) [1] |
Your dose and schedule are set by your prescriber.
From the label to the app
| What the label says | What PepLabo does with it |
|---|---|
| One tablet once daily, with or without food; no water or fasting rule is given [1]. | A daily reminder and a tablet pack that counts down; no unit math, vial or water. |
| If a dose is missed, take it as soon as possible [1]. | A follow-up arrives 30 minutes after the dose time; the log keeps the time you actually took it. |
What PepLabo does and does not do
| PepLabo does | PepLabo does not |
|---|---|
| Record each dose with the date, time and amount you enter, and the site for injections | Suggest a dose, a schedule change or a medicine |
| Remind you 15 minutes before, at the dose time, and 30 minutes after a missed dose | Tell you what to do after a missed dose; the leaflet and your prescriber do |
| Put check-ins, weight and doses on one timeline | Interpret symptoms or judge progress |
| Keep your records on your phone, with no account needed to track | Use analytics, advertising or tracking SDKs, or write to Apple Health |
| Create a PDF of your dose log for your clinician (Pro) | Replace your clinician or pharmacist |
